2020 was a year turned upside-down by the novel coronavirus. But with the prospect of several vaccines coming online and less stringent restrictions, experts say it's possible 2021 will return to a semblance of normality.
With a second COVID-19 wave currently battering Europe, the United States battling its third, and Hong Kong facing a fourth, disease specialists say they can't rule out more resurgences in cases and deaths as 2021 gets underway.
France's scientific council, which guides government policy on the pandemic, envisages "several successive waves" of COVID-19 over the winter and well into next year.
Flavio Toxvaerd, lecturer at the University of Cambridge's Faculty of Economics, told AFP the question of how many waves the world still faces depends on a variety of factors.
These include "seasonal changes in contact patterns as well as how well the disease is managed through a combination of social distancing and vaccines," said Toxvaerd, who specializes in the economics of infectious diseases and economic epidemiology.
Lessons learned from past interventions could allow countries to fine-tune their counter-virus measures, implementing modified restrictions while avoiding total lockdowns.
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Governments will seek to administer "the minimal effective dose" of measures, such as bans on large gatherings or high-risk activities, according to Anne-Claude Cremieux, an infectious diseases expert at Paris' Saint-Louis hospital.
She referred to a strategy of "surgical strikes" against the virus.
That would require full knowledge and control over the transmission chain, with an effective "test, trace, isolate" system and particular care taken over protecting vulnerable and elderly individuals.
"We need to hold on until relief arrives, and the relief is a vaccine," said Cremieux.
She however cautioned that "it's clear we're not going to vaccinate the entire world in six months."
Even if several vaccines are made available, they alone will not be enough to return to normal.
Arnaud Fontanet, an epidemiologist at the Pasteur Institute told RMC/BFMTV television that normality could be restored "only by Autumn 2021" -- and even then only if 80-90 percent of the population are vaccinated.
Universal coverage would be "an extremely ambitious goal given the hesitancy that exists today towards vaccines," he said.
Fontanet echoed concerns expressed by fellow experts that a massive effort is needed to overcome anti-vaccine sentiment worldwide.
With some countries debating making COVID-19 vaccinations mandatory, Toxvaerd sounded a note of caution.
"In the current climate, making vaccines mandatory may backfire and cause even more resistance to the vaccine," he said.
"Instead, positive incentives to vaccinate should be considered."
He pointed to certain business and social practices -- such as some airlines refusing to admit non-vaccinated passengers -- that would be more likely to bring success than enforced vaccination programs.
And the logistics of mass vaccination remain dizzying. Even as results from trials need verifying in peer-reviewed papers, little still is known about how long the immunity they render will last.
Fontanet said that even the most effective vaccines could not be treated as a magic wand guaranteeing protection.
"There will be people who have been vaccinated who still get sick," he said.
But he stressed that didn't mean that "the vaccine doesn't work."
With at least two candidate vaccines undergoing review by health authorities ahead of user authorization, the safety data from trials is also being pored over.
"This can provide important additional and more precise information on longer-term safety and efficacy of a vaccine against COVID-19," the European Medicines Agency said recently.
Different vaccines will need to be distributed differently, too, with some candidates that have proven to prevent severe illness likely prioritized for at-risk individuals.
Moncef Slaoui, head scientist with the US's Operation Warp Speed vaccination program, told CNN last month that around 70% of the population would need inoculating in order to achieve "true herd immunity."
This level is unlikely to be reached before May 2021, he added.
Masks: not just for 2020
This year has seen an unprecedented change in personal behavior prompted by COVID-19, from hand washing and social distancing to the now almost ubiquitous mask-wearing.
Experts say these behaviors are unlikely to be limited to 2020 alone, as protective measures will still be needed until everyone is out of the woods.
Leading U.S. scientist Anthony Fauci told AFP in a recent interview he foresaw "a considerable degree of normality" by the third quarter of next year.
Successful vaccination programs could see for example the Olympic Games, delayed from last summer, take place in Tokyo in late July.
Meanwhile, China, where COVID-19 emerged late last year, has largely resumed business as usual, while developing its own vaccine and reacting swiftly to any hint of new cases.